Prolyl hydroxylase inhibitors increase the production of vascular endothelial growth factor by periodontal fibroblasts.

@article{Agis2012ProlylHI,
  title={Prolyl hydroxylase inhibitors increase the production of vascular endothelial growth factor by periodontal fibroblasts.},
  author={Hermann Agis and Georg Watzek and Reinhard Gruber},
  journal={Journal of periodontal research},
  year={2012},
  volume={47 2},
  pages={
          165-73
        }
}
BACKGROUND AND OBJECTIVE Pharmacological inhibitors of prolyl hydroxylases (PHDs) can induce a proangiogenic response that favors wound healing and bone regeneration. However, the response of periodontal cells to PHD inhibitors is unknown. MATERIAL AND METHODS To determine the effects of PHD inhibitors on periodontal cells, we exposed human fibroblasts from the gingiva and the periodontal ligament to dimethyloxallyl glycine, desferrioxamine, l-mimosine and CoCl(2). Viability, proliferation… CONTINUE READING
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