Prolyl hydroxylase inhibitor dimethyloxalylglycine enhances mesenchymal stem cell survival.

@article{Liu2009ProlylHI,
  title={Prolyl hydroxylase inhibitor dimethyloxalylglycine enhances mesenchymal stem cell survival.},
  author={Xian-bao Liu and Jian'an Wang and Molly E. Ogle and Ling Wei},
  journal={Journal of cellular biochemistry},
  year={2009},
  volume={106 5},
  pages={903-11}
}
Mesenchymal stem cell (MSC) transplantation is a promising approach in the therapy of ischemic heart or CNS diseases; however, the poor viability of MSCs after transplantation critically limits the efficacy of this new strategy. Prolyl hydroxylase inhibition followed by HIF-1alpha up-regulation participates in the regulation of apoptosis and cell survival, which have been shown in cancer cells and neurons. The role of prolyl hydroxylase inhibition by dimethyloxalylglycine (DMOG) in regulation… CONTINUE READING

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