Prolyl hydroxylase-3 is down-regulated in colorectal cancer cells and inhibits IKKbeta independent of hydroxylase activity.

@article{Xue2010ProlylHI,
  title={Prolyl hydroxylase-3 is down-regulated in colorectal cancer cells and inhibits IKKbeta independent of hydroxylase activity.},
  author={Jing Xue and Xuebing Li and Shi Jiao and Ye Ding Wei and Guo-Hao Wu and Jing Fang},
  journal={Gastroenterology},
  year={2010},
  volume={138 2},
  pages={
          606-15
        }
}
BACKGROUND & AIMS Prolyl hydroxylase (PHD) hydroxylates hypoxia inducible factor (HIF) alpha, leading to HIFalpha degradation. The PHD family comprises PHD1, PHD2, and PHD3. The enzymatic activity of PHDs is O(2)-dependent, so PHDs are believed to be oxygen sensors as well as tumor suppressors. However, the expression pattern of PHDs in colorectal cancer and the correlation between their expression level and tumorigenesis is unclear. METHODS We determined the expression of PHDs in 60 human… CONTINUE READING
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