Prolyl endopeptidase mRNA expression in the central nervous system during rat development.

@article{Agirregoitia2010ProlylEM,
  title={Prolyl endopeptidase mRNA expression in the central nervous system during rat development.},
  author={N Agirregoitia and Patrice Bizet and Ekaitz Agirregoitia and Isabelle Boutelet and Laura Peralta and Hubert Vaudry and Sylvie J{\'e}gou},
  journal={Journal of chemical neuroanatomy},
  year={2010},
  volume={40 1},
  pages={53-62}
}
Prolyl endopeptidase (PEP) is a serine protease that cleaves small peptides at the carboxyl side of L-proline. PEP has been reported to have important functions in the brain being implicated in learning and memory processes, psychological disorders and neurodegenerative diseases. Several PEP substrates have been shown to play a role during brain development and this observation led us to investigate the expression of PEP mRNA in the rat brain and spinal cord, from embryo to adult stages. In… CONTINUE READING