Prolyl endopeptidase catalysis. A physical rather than a chemical step is rate-limiting.

@article{Polgar1992ProlylEC,
  title={Prolyl endopeptidase catalysis. A physical rather than a chemical step is rate-limiting.},
  author={László Polgár},
  journal={The Biochemical journal},
  year={1992},
  volume={283 ( Pt 3)},
  pages={
          647-8
        }
}
  • L. Polgár
  • Published 1992
  • Chemistry, Medicine
  • The Biochemical journal
Prolyl endopeptidase represents a new family of serine proteases, and it has a mechanistic feature distinct from that of the enzymes of the extensively studied chymotrypsin and subtilisin families. The rate-determining step in the catalysis of serine proteases is a general base/acid-catalysed chemical step. For prolyl endopeptidase, however, the chemical step is not rate-limiting, as demonstrated by using substrates with different leaving groups. It is known that the acylation of chymotrypsin… Expand
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