Prolyl Oligopeptidase An Unusual β-Propeller Domain Regulates Proteolysis

@article{Flp1998ProlylOA,
  title={Prolyl Oligopeptidase An Unusual $\beta$-Propeller Domain Regulates Proteolysis},
  author={V. F{\"u}l{\"o}p and Z. B{\"o}cskei and L. Polgár},
  journal={Cell},
  year={1998},
  volume={94},
  pages={161-170}
}
Abstract Prolyl oligopeptidase is a large cytosolic enzyme that belongs to a new class of serine peptidases. The enzyme is involved in the maturation and degradation of peptide hormones and neuropeptides, which relate to the induction of amnesia. The 1.4 A resolution crystal structure is presented here. The enzyme contains a peptidase domain with an α/β hydrolase fold, and its catalytic triad (Ser554, His680, Asp641) is covered by the central tunnel of an unusual β propeller. This domain makes… Expand

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  • L. Polgár
  • Chemistry, Medicine
  • Cellular and Molecular Life Sciences CMLS
  • 2002
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