Prolyl 4-hydroxylation regulates Argonaute 2 stability

@article{Qi2008Prolyl4R,
  title={Prolyl 4-hydroxylation regulates Argonaute 2 stability},
  author={H. Qi and P. Ongusaha and J. Myllyharju and Dongmei Cheng and Outi Pakkanen and Y. Shi and Sam W. Lee and Junmin Peng and Yang Shi},
  journal={Nature},
  year={2008},
  volume={455},
  pages={421-424}
}
Human Argonaute (Ago) proteins are essential components of the RNA-induced silencing complexes (RISCs). Argonaute 2 (Ago2) has a P-element-induced wimpy testis (PIWI) domain, which folds like RNase H and is responsible for target RNA cleavage in RNA interference. Proteins such as Dicer, TRBP, MOV10, RHA, RCK/p54 and KIAA1093 associate with Ago proteins and participate in small RNA processing, RISC loading and localization of Ago proteins in the cytoplasmic messenger RNA processing bodies… Expand
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