Prolotherapy for Osteoarthritis and Tendinopathy: a Descriptive Review

  title={Prolotherapy for Osteoarthritis and Tendinopathy: a Descriptive Review},
  author={David Rabago and Bobby Nourani},
  journal={Current Rheumatology Reports},
Purpose of ReviewOsteoarthritis and overuse tendinopathy are common chronic conditions of high societal and patient burden. The precise etiology of pain and disability in both conditions is multifactorial and not well understood. Patients are often refractory to conservative therapy. The development of new therapeutic options in both conditions is a public health priority. Prolotherapy is an injection-based outpatient regenerative therapy for chronic musculoskeletal conditions, including… 

Sclerotherapy and prolotherapy for chronic patellar tendinopathies - a promising therapy with limited available evidence, a systematic review

There seems to be some evidence that ST and PT may be effective treatment options to treat pain and to improve function in patients with CPT, but more research is needed with larger volume studies and randomized controlled studies with long term follow up.

Injection therapies for patellar tendinopathy

  • S. Nuhmani
  • Medicine
    The Physician and sportsmedicine
  • 2019
The literature reveals many different injection methods are being used by clinicians for the treatment of patellar tendinopathy, and Platelet rich plasma, corticosteroids, autologous blood, and aprotinin are the most commonly used injection treatments.

Prolotherapy: review with background history, mechanism of action, and current evidence

Prolotherapy is a type of therapy that involves injections of an irritant solution into joints, tendons or ligaments to spur an inflammatory response that can expedite healing in damaged tissues. It

Temporal tendinosis: A cause of chronic orofacial pain

Temporal tendinosis is an under-recognised and under-treated condition and training for diagnosis and manage of temporal tendinopathy among primary care physicians in both medical and dental professions is inadequate.

Prolotherapy for knee osteoarthritis using hypertonic dextrose vs other interventional treatments: systematic review of clinical trials

Although HDP seems to be a promising interventional treatment for knee OA, more studies with better methodological quality and low risk of bias are needed to confirm the efficacy and safety of this intervention.

A Population-Level Summary of Health Care Utilization for the Management of Patellar Tendinopathy in the Military Health System.

Exercise therapy was the most common intervention used during the initial episode of care, but exercise therapy did not influence the recurrence of knee pain.

Ultrasound-observed tendon abnormalities in lateral epicondylalgia: Exploring associations with neurosensory and clinical outcomes

This thesis demonstrates that the composite US scoring method has good inter-and intra-rater reliability in grading tendon abnormalities in LE and investigates the effectiveness of prolotherapy injections, manual therapy/exercise, both singly and in combination in improving tendon structural and sensory abnormalities over time.

Whiplash injury successfully treated with prolotherapy: a case report with long-term follow up.

Background: Chronic whiplash-associated disorder (WAD) can develop after flexion/extension injuries and may be refractory to standard-of-care therapies. Aim: To present successful treatment of

Regenerative Pain Medicine, the New Era of Interventional Pain Management, Restart Now!

Prolotherapy, especially dextrose prolotherapy, has become a promising technique by providing a safe degenerative therapy, easy to performed, and highly available in health facilities.

The Effects of Dextrose Prolotherapy in Symptomatic Knee Osteoarthritis: A Randomized Controlled Study.

Findings suggest that dextrose prolotherapy is effective at reducing pain and improving the functional status and quality of life of patients with KOA.



A Systematic Review of Prolotherapy for Chronic Musculoskeletal Pain

There are limited high-quality data supporting the use of prolotherapy in the treatment of musculoskeletal pain or sport-related soft tissue injuries, and positive results compared with controls have been reported in nonrandomized and randomized controlled trials.

Common overuse tendon problems: A review and recommendations for treatment.

Outpatient treatment for overuse tendinopathies should consist of relative rest of the affected area, icing, and eccentric strengthening exercises, and topical and systemic nonsteroidal anti-inflammatory drugs are effective for acute pain relief, these cannot be recommended in favor of other analgesics.

Dextrose Prolotherapy for Knee Osteoarthritis: A Randomized Controlled Trial

Prolotherapy resulted in clinically meaningful sustained improvement of pain, function, and stiffness scores for knee osteoarthritis compared with blinded saline injections and at-home exercises and use of prescribed postprocedure opioid medication.

Time to abandon the “tendinitis” myth

Doctors should acknowledge that painful overuse tendon conditions have a non-inflammatory pathology and stop adhering to the myths above.

Hypertonic dextrose injections (prolotherapy) in the treatment of symptomatic knee osteoarthritis: A systematic review and meta-analysis

Overall, prolotherapy conferred a positive and significant beneficial effect in the treatment of knee OA, and adequate powered, longer-term trials with uniform end points are needed to better elucidate the efficacy of prolotherapy.

Hypertonic dextrose injections (prolotherapy) for knee osteoarthritis: results of a single-arm uncontrolled study with 1-year follow-up.

In adults with moderate to severe KOA, dextrose prolotherapy may result in safe, significant, sustained improvement of knee pain, function, and stiffness scores.

Platelet-Rich Plasma Intra-articular Knee Injections Show No Superiority Versus Viscosupplementation

PRP does not provide a superior clinical improvement with respect to HA, and therefore it should not be preferred to viscosupplementation as injective treatment of patients affected by knee cartilage degeneration and OA.

Qualitative Assessment of Patients Receiving Prolotherapy for Knee Osteoarthritis in a Multimethod Study.

Most participants reported substantially improved knee-specific effects, resulting in improved quality of life and activities of daily living, and clear, complete description of procedural rationale may enhance optimism about and adherence to treatment appointments.