Prolotherapy: A Clinical Review of Its Role in Treating Chronic Musculoskeletal Pain

  title={Prolotherapy: A Clinical Review of Its Role in Treating Chronic Musculoskeletal Pain},
  author={Laura M. L. Distel and Thomas M. Best},
Evidence-based use of proloterapy in treating musculoskeletal pain
Prolotherapy remains a promising option for the treatment of musculoskeletal pain when other standard treatments have proven to be ineffective, however, further large-scale and well designed clinical studies are needed to obtain more objective evidences.
Prolotherapy and Low Level Laser Therapy: A Synergistic Approach to Pain Management in Chronic Osteoarthritis
The authors suggest that practicing health care providers consider utilizing LLLT and prolotherapy together as a supplementary method in the management of chronic pain due to osteoarthritis, to minimize the long-term prescription of opioids and emphasize a less invasive treatment for this debilitating condition.
Injection therapies for patellar tendinopathy
  • S. Nuhmani
  • Medicine
    The Physician and sportsmedicine
  • 2019
The literature reveals many different injection methods are being used by clinicians for the treatment of patellar tendinopathy, and Platelet rich plasma, corticosteroids, autologous blood, and aprotinin are the most commonly used injection treatments.
Joint Instability as the Cause of Chronic Musculoskeletal Pain and Its Successful Treatment with Prolotherapy
  • R. Hauser, B. Woldin
  • Biology, Engineering
    Anatomy, Posture, Prevalence, Pain, Treatment and Interventions of Musculoskeletal Disorders
  • 2018
This chapter is based on the premise that treatment with prolotherapy can greatly reduce chronic musculoskeletal pain, which affects more than 1 billion people worldwide. Although relatively unknown
Effectiveness of prolotherapy in the treatment of chronic rotator cuff lesions.
A Systematic Review of Dextrose Prolotherapy for Chronic Musculoskeletal Pain
Use of dextrose prolotherapy is supported for treatment of tendinopathies, knee and finger joint OA, and spinal/pelvic pain due to ligament dysfunction and in acute pain, as first-line therapy, and in myofascial pain cannot be determined from the literature.
Chronic Neck Pain: Making the Connection Between Capsular Ligament Laxity and Cervical Instability
It is proposed that prolotherapy offers a potentially curative treatment option for chronic neck pain related to capsular ligament laxity and underlying cervical instability, and is presented as a viable treatment option that heals injured ligaments, restores stability to the spine, and resolves chronic neckPain.
Ultrasound-guided dextrose injection treatment for chronic myofascial pain syndrome: A retrospective case series
Targeted ultrasound-guided dextrose injection was remarkably effective for refractory localized myofascial pain syndrome, significantly reducing symptom intensities in the majority of treated patients within 1 month after a single injection.
Efficacy of Prolotherapy in Temporomandibular Joint Disorders: An Exploratory Study
It is concluded that prolotherapy is an effective therapeutic modality that reduces TMJ pain, improves joint stability and range of motion in a majority of patients and can be a first-line treatment option as it is safe, economical and an easy procedure associated with minimal morbidity.
Hypertonic dextrose injections (prolotherapy) in the treatment of symptomatic knee osteoarthritis: A systematic review and meta-analysis
Overall, prolotherapy conferred a positive and significant beneficial effect in the treatment of knee OA, and adequate powered, longer-term trials with uniform end points are needed to better elucidate the efficacy of prolotherapy.


A Systematic Review of Prolotherapy for Chronic Musculoskeletal Pain
There are limited high-quality data supporting the use of prolotherapy in the treatment of musculoskeletal pain or sport-related soft tissue injuries, and positive results compared with controls have been reported in nonrandomized and randomized controlled trials.
Prolotherapy injections for chronic low-back pain.
There is conflicting evidence regarding the efficacy of prolotherapy injections in reducing pain and disability in patients with chronic low-back pain, and in the presence of co-interventions, Prolotherapy injections were more effective than control injections, more so when both injections and co- interventions were controlled concurrently.
A randomized controlled trial of intra-articular prolotherapy versus steroid injection for sacroiliac joint pain.
Intra-articular prolotherapy provided significant relief of sacroiliac joint pain, and its effects lasted longer than those of steroid injections, and to confirm the safety of the procedure and to validate an appropriate injection protocol.
Prolotherapy Injections, Saline Injections, and Exercises for Chronic Low-Back Pain: A Randomized Trial
Ligament injections, with exercises and with normal activity, resulted in significant and sustained reductions in pain and disability throughout the trial, but no attributable effect was found for prolotherapy injections over saline injections or for exercises over normal activity.
Prolotherapy injections and eccentric loading exercises for painful Achilles tendinosis: a randomised trial
For Achilles tendinosis, prolotherapy and particularly ELE combined with prolotherapy give more rapid improvements in symptoms than ELE alone but long-term VISA-A scores are similar.
The Efficacy of Prolotherapy for Lateral Epicondylosis: A Pilot Study
Prolotherapy with dextrose and sodium morrhuate was well tolerated, effectively decreased elbow pain, and improved strength testing in subjects with refractory lateral epicondylosis compared to Control group injections.
A randomized, double-blind, placebo-controlled trial of sclerosing injections in patients with chronic low back pain.
Three, weekly sclerosant injections alone may not be effective treatment in many patients with undifferentiated chronic back pain, and patient selection and combination with other treatment modalities may be factors in determining treatment success.
Treatment of painful advanced internal lumbar disc derangement with intradiscal injection of hypertonic dextrose.
The results suggest that intradiscal injection of hypertonic dextrose may have a place in the management of pain arising from advanced lumbar degenerative disc disease.