Prolonged treatment with pegylated interferon alpha 2b plus ribavirin improves sustained virological response in chronic hepatitis C genotype 1 patients with late response in a clinical real-life setting in Japan.

@article{Watanabe2010ProlongedTW,
  title={Prolonged treatment with pegylated interferon alpha 2b plus ribavirin improves sustained virological response in chronic hepatitis C genotype 1 patients with late response in a clinical real-life setting in Japan.},
  author={Sumio Watanabe and Nobuyuki Enomoto and Kazuhiko Koike and Namiki Izumi and Hajime Takikawa and Etsuko Hashimoto and Fuminori Moriyasu and Hiromitsu Kumada and Michio Imawari},
  journal={Hepatology research : the official journal of the Japan Society of Hepatology},
  year={2010},
  volume={40 2},
  pages={135-44}
}
AIM This study was conducted to clarify the factors related to sustained virological response (SVR) to pegylated interferon alpha 2b (PEG-IFN) plus ribavirin (RBV) combination therapy administered for 48 weeks in patients with chronic hepatitis C virus (CHCV) and to evaluate the usefulness of prolonged treatment in patients with late virological response (LVR). METHODS Of 2257 patients registered at 68 institutions, those with genotype 1 and high viral load were selected to participate in two… CONTINUE READING