Prolonged treadmill training increases HSP70 in skeletal muscle but does not affect age-related functional deficits.

@article{Kayani2008ProlongedTT,
  title={Prolonged treadmill training increases HSP70 in skeletal muscle but does not affect age-related functional deficits.},
  author={Anna C. Kayani and Graeme Leonard Close and Malcolm J. Jackson and Anne McArdle},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2008},
  volume={294 2},
  pages={R568-76}
}
Skeletal muscle atrophy and weakness are major causes of frailty in the elderly. Functional deficits in muscles of old humans and rodents are associated with attenuated production of heat shock proteins (HSPs) after exercise, and transgenic overexpression of HSP70 reverses this functional decline. We hypothesized that training would increase HSP70 content of muscle in adult and old wild-type mice and that this would protect against the development of age-related functional deficits. A 10-wk… CONTINUE READING

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Exercise training decreases DNA damage and R575 EFFECT OF INCREASED HSP70 WITH TRAINING ON AGING MUSCLES AJP-Regul

  • Z Radak, H Naito, +5 authors S. Goto
  • Integr Comp Physiol
  • 2008
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