Prolonged survival of transplanted islets of Langerhans encapsulated in a biocompatible membrane.

@article{OShea1984ProlongedSO,
  title={Prolonged survival of transplanted islets of Langerhans encapsulated in a biocompatible membrane.},
  author={Greg O'Shea and Mattheus F. A. Goosen and Anthony M. Sun},
  journal={Biochimica et biophysica acta},
  year={1984},
  volume={804 1},
  pages={133-6}
}
Prolonged survival of islet allografts in streptozotocin-induced diabetic rats was achieved by encapsulating individual islets in protective, biocompatible alginate-polylysine-alginate membranes. A single intraperitoneal transplant of encapsulated islets reversed the diabetic state for up to 1 year. In contrast, a single injection of unencapsulated islets was effective for less than 2 weeks. The microencapsulation procedure, by protecting transplanted tissue from the components of the immune… CONTINUE READING