Prolonged survival of a murine model of cerebral malaria by kynurenine pathway inhibition.

@article{Clark2005ProlongedSO,
  title={Prolonged survival of a murine model of cerebral malaria by kynurenine pathway inhibition.},
  author={Catherine J Clark and Gillian M. Mackay and George A. Smythe and Sonia Bustamante and Trevor W Stone and Ralph Phillips},
  journal={Infection and immunity},
  year={2005},
  volume={73 8},
  pages={5249-51}
}
C57BL/6J mice infected with Plasmodium berghei ANKA develop neurological dysfunction and die within 7 days of infection. We show that treatment of infected mice with a kynurenine-3-hydroxylase inhibitor prevents them from developing neurological symptoms and extends their life span threefold until severe anemia develops. 

From This Paper

Figures, tables, and topics from this paper.
44 Citations
21 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 44 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 21 references

Similar Papers

Loading similar papers…