Prolonged suppression of human immunodeficiency virus type 1 (HIV-1) viremia in persons with advanced disease results in enhancement of CD4 T cell reactivity to microbial antigens but not to HIV-1 antigens.

@article{Rinaldo1999ProlongedSO,
  title={Prolonged suppression of human immunodeficiency virus type 1 (HIV-1) viremia in persons with advanced disease results in enhancement of CD4 T cell reactivity to microbial antigens but not to HIV-1 antigens.},
  author={Charles R. Rinaldo and Jeffery M Liebmann and X L Huang and Zheng Fan and Q Al-shboul and Deborah K McMahon and Richard D. Day and Sharon A. Riddler and John W Mellors},
  journal={The Journal of infectious diseases},
  year={1999},
  volume={179 2},
  pages={329-36}
}
CD4 T cell responses were studied for >2 years in 27 zidovudine-experienced patients with advanced human immunodeficiency virus type 1 (HIV-1) infection who received triple combination drug therapy with indinavir, zidovudine and lamivudine or zidovudine plus lamivudine or zidovudine alone for 24-42 weeks before switching to the three-drug therapy. Subjects initially given the three drugs had viremia suppressed to undetectable levels and increases in T cell proliferative and cytokine responses… CONTINUE READING

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