Prolonged submaximal exercise induces isoform-specific Na+-K+-ATPase mRNA and protein responses in human skeletal muscle.

@article{Murphy2006ProlongedSE,
  title={Prolonged submaximal exercise induces isoform-specific Na+-K+-ATPase mRNA and protein responses in human skeletal muscle.},
  author={Kate T. Murphy and Aaron C. Petersen and Craig A. Goodman and Xiaofei Gong and James A Leppik and Andrew P. Garnham and David Cameron-Smith and Rodney J. Snow and Michael J. McKenna},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2006},
  volume={290 2},
  pages={
          R414-24
        }
}
  • K. Murphy, A. Petersen, +6 authors M. McKenna
  • Published 1 February 2006
  • Biology
  • American journal of physiology. Regulatory, integrative and comparative physiology
This study investigated effects of prolonged submaximal exercise on Na+-K+-ATPase mRNA and protein expression, maximal activity, and content in human skeletal muscle. We also investigated the effects on mRNA expression of the transcription initiator gene, RNA polymerase II (RNAP II), and key genes involved in protein translation, eukaryotic initiation factor-4E (eIF-4E) and 4E-binding protein 1 (4E-BP1). Eleven subjects (6 men, 5 women) cycled at 75.5% (SD 4.8%) peak O2 uptake and continued… 
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TLDR
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Effect of exercise and training on phospholemman phosphorylation in human skeletal muscle.
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It is shown that only acute exercise, and not short-term training, increases phosphorylation of PLM on Ser(63) and Ser(68), and data from one-legged cycling indicate that this effect of exercise on PLM phosphorylated is not due to systemic factors.
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