Prolonged stationary-phase incubation selects for lrp mutations in Escherichia coli K-12.

@article{Zinser2000ProlongedSI,
  title={Prolonged stationary-phase incubation selects for lrp mutations in Escherichia coli K-12.},
  author={Erik R Zinser and Roberto Kolter},
  journal={Journal of bacteriology},
  year={2000},
  volume={182 15},
  pages={4361-5}
}
Evolution by natural selection occurs in cultures of Escherichia coli maintained under carbon starvation stress. Mutants of increased fitness express a growth advantage in stationary phase (GASP) phenotype, enabling them to grow and displace the parent as the majority population. The first GASP mutation was identified as a loss-of-function allele of rpoS, encoding the stationary-phase global regulator, sigma(S) (M. M. Zambrano, D. A. Siegele, M. A. Almirón, A. Tormo, and R. Kolter, Science 259… CONTINUE READING

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