Prolonged somatostatin therapy may cause down-regulation of SSTR-like GPCRs on Schistosoma mansoni.

@article{Chatterjee2007ProlongedST,
  title={Prolonged somatostatin therapy may cause down-regulation of SSTR-like GPCRs on Schistosoma mansoni.},
  author={Shyama Chatterjee and Jeff Op de Beeck and A. Venketeshwer Rao and Dattatraya Venkatesh Desai and Gunther Vrolix and Frank Rylant and Thomas Panis and Amit Bernat and Jonathan Van Bergen and Dieter Peeters and Eric van Marck},
  journal={Journal of vector borne diseases},
  year={2007},
  volume={44 3},
  pages={164-80}
}
BACKGROUND & OBJECTIVES Chemotherapy with praziquantel remains the only control measure to Schistosoma mansoni infections to date. The neuropeptide hormone somatostatin gives relief from gastrointestinal disturbances, liverpathology, and reduces egg production in S. mansoni infected mice, suggesting an interaction of somatostatin with the parasite rather than with the host alone. Using antibodies directed to epitopes of the seven somatostatin transmembrane receptors (SSTRs), the presence of… CONTINUE READING