Prolonged sodium channel inactivation contributes to dendritic action potential attenuation in hippocampal pyramidal neurons.

@article{Jung1997ProlongedSC,
  title={Prolonged sodium channel inactivation contributes to dendritic action potential attenuation in hippocampal pyramidal neurons.},
  author={Han Young Jung and T Mickus and Nelson Spruston},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1997},
  volume={17 17},
  pages={6639-46}
}
During low-frequency firing, action potentials actively invade the dendrites of CA1 pyramidal neurons. At higher firing rates, however, activity-dependent processes result in the attenuation of back-propagating action potentials, and propagation failures occur at some dendritic branch points. We tested two major hypotheses related to this activity-dependent attenuation of back-propagating action potentials: (1) that it is mediated by a prolonged form of sodium channel inactivation and (2) that… CONTINUE READING
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A decrease in Na 1 current contributes to loss of action potential amplitude in dendritic spike trains

  • CM Colbert, D Johnston
  • Soc Neurosci Abstr
  • 1996
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