Prolonged secretion of cortisol as a possible mechanism underlying stress and depressive behaviour
@article{Qin2016ProlongedSO, title={Prolonged secretion of cortisol as a possible mechanism underlying stress and depressive behaviour}, author={Dong-dong Qin and Joshua Dominic Rizak and Xiao-li Feng and Shangchuan Yang and Long-bao L{\"u} and Lei Pan and Yong Yin and Xin-tian Hu}, journal={Scientific Reports}, year={2016}, volume={6} }
Stress is associated with the onset of depressive episodes, and cortisol hypersecretion is considered a biological risk factor of depression. However, the possible mechanisms underlying stress, cortisol and depressive behaviours are inconsistent in the literature. This study examined the interrelationships among stress, cortisol and observed depressive behaviours in female rhesus macaques for the first time and explored the possible mechanism underlying stress and depressive behaviour. Female…
43 Citations
Circulating Cortisol in a Cohort of Depressive Patients
- Psychology, MedicineCurrent health sciences journal
- 2020
This study aimed to evaluate HPA functionality by evaluating plasma cortisol levels in a cohort of patients diagnosed with Major Depressive Disorder and did not find a significant association between cortisol levels and the number of previous depressive episodes, the presence of feelings of anxiety, suicidal ideas or suicidal gestures.
Cortisol and Major Depressive Disorder—Translating Findings From Humans to Animal Models and Back
- Biology, PsychologyFrontiers in Psychiatry
- 2019
It is argued that the absolute level of cortisol is unreliable for predicting the efficacy of antidepressant treatment and it is proposed that future preclinical models should reliably produce exaggerated HPA axis responses to acute or chronic stress a priori, which may, or may not, alter baseline cortisol levels.
A momentary assessment study on emotional and biological stress in adult males and females with autism spectrum disorder
- PsychologyScientific reports
- 2021
Prospective momentary psychological and biological measures of real-time daily life stress experiences have been examined in several psychiatric disorders, but not in adults with an autism spectrum…
Midday and nadir salivary cortisol appear superior to cortisol awakening response in burnout assessment and monitoring
- Psychology, MedicineScientific Reports
- 2018
The treatment program resulted in a significant reduction of stress, anxiety, and depression scores, and the potential usefulness of midday and nadir salivary cortisol as markers in the assessment and biomonitoring of burnout is emphasized.
Effects of Aerobic Exercise on Cortisol Stress Reactivity in Response to the Trier Social Stress Test in Inpatients with Major Depressive Disorders: A Randomized Controlled Trial
- Psychology, MedicineJournal of clinical medicine
- 2020
Aerobic exercise training was not associated with patients’ stress reactivity in this study, and the association between change in depression and cortisol response via correlational analysis did not change from baseline to post-intervention.
The Combination of Serum BDNF, Cortisol and IFN-Gamma Can Assist the Diagnosis of Major Depressive Disorder
- Medicine, BiologyNeuropsychiatric disease and treatment
- 2021
Results showed that combining serum BDNF, cortisol and IFN-gamma could aid the diagnosis of MDD, while baseline retardation and psychological anxiety may predict the poor early symptom improvement.
Microglia and HPA axis in depression: an overview of participation and relationship.
- BiologyThe world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
- 2021
This study aimed to provide an overview on the involvement of microglia and the HPA axis in the pathophysiology of depression, as well as to investigate the mutual relationship between these two entities: how microglial activation can contribute to the dysregulation of the H PA axis, and vice versa.
Melatonergic agonist regulates circadian clock genes and peripheral inflammatory and neuroplasticity markers in patients with depression and anxiety
- Medicine, PsychologyBrain, Behavior, and Immunity
- 2020
Chronic unpredictable mild stress produces depressive-like behavior, hypercortisolemia, and metabolic dysfunction in adolescent cynomolgus monkeys
- Psychology, BiologyTranslational Psychiatry
- 2021
CUMS can induce depressive-like and anxiety-like behaviors, hypercortisolemia, and metabolic perturbations in adolescent cynomolgus monkeys and is a promising model to study the mechanisms underlying adolescent depression.
Cortisol on Circadian Rhythm and Its Effect on Cardiovascular System
- Biology, MedicineInternational journal of environmental research and public health
- 2021
The role of 11β-hydroxysteroid dehydrogenase (11β-HSD1) is discussed, which is a novel molecular target of interest for treating metabolic syndrome and type-2 diabetes mellitus and provides a platform for future potential cardioprotective therapeutic agents.
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