Prolonged saturated fat-induced, glucose-dependent insulinotropic polypeptide elevation is associated with adipokine imbalance and liver injury in nonalcoholic steatohepatitis: dysregulated enteroadipocyte axis as a novel feature of fatty liver.

@article{Musso2009ProlongedSF,
  title={Prolonged saturated fat-induced, glucose-dependent insulinotropic polypeptide elevation is associated with adipokine imbalance and liver injury in nonalcoholic steatohepatitis: dysregulated enteroadipocyte axis as a novel feature of fatty liver.},
  author={Giovanni Musso and Roberto Gambino and Giovanni Pacini and Franco De Michieli and Maurizio Cassader},
  journal={The American journal of clinical nutrition},
  year={2009},
  volume={89 2},
  pages={558-67}
}
BACKGROUND Genetic and acquired mechanisms underlying the association of nonalcoholic fatty liver disease (NAFLD) with diabetes are unknown. Glucose-dependent insulinotropic polypeptide (GIP) was recently linked to adipocyte metabolism and obesity-related metabolic disorders, including NAFLD, induced by an excess of saturated fatty acids (SFAs), but its role in vivo, as well as underlying mechanisms, is unknown. We hypothesized that altered GIP secretion may contribute to the pathogenesis of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 36 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 53 references

Incretin mimetics as a novel therapeutic option for hepatic steatosis.

Liver international : official journal of the International Association for the Study of the Liver • 2006
View 11 Excerpts
Highly Influenced

Real-time assessment of postprandial fat storage in liver and skeletal muscle in health and type 2 diabetes.

American journal of physiology. Endocrinology and metabolism • 2005
View 9 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…