Prolonged release melatonin for improving sleep in totally blind subjects: a pilot placebo-controlled multicenter trial

@inproceedings{Roth2015ProlongedRM,
  title={Prolonged release melatonin for improving sleep in totally blind subjects: a pilot placebo-controlled multicenter trial},
  author={Thomas Roth and Tali Nir and Nava Zisapel},
  booktitle={Nature and science of sleep},
  year={2015}
}
INTRODUCTION Melatonin, secreted by the pineal gland during the night phase, is a regulator of the biological clock and sleep tendency. Totally blind subjects frequently report severe, periodic sleep problems, with 50%-75% of cases displaying non-24-hour sleep-wake disorder (N24HSWD) due to inability to synchronize with the environmental day-night cycle. Melatonin immediate-release preparations are reportedly effective in N24HSWD. Here, we studied the efficacy and safety of prolonged-release… CONTINUE READING
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