Prolonged-release formulation of melatonin (Circadin) for the treatment of insomnia

@article{Lemoine2012ProlongedreleaseFO,
  title={Prolonged-release formulation of melatonin (Circadin) for the treatment of insomnia},
  author={P. Lemoine and N. Zisapel},
  journal={Expert Opinion on Pharmacotherapy},
  year={2012},
  volume={13},
  pages={895 - 905}
}
Introduction: Insomnia is common among the elderly. The use of hypnotic drugs in elderly patients is frequently criticized owing to dependency, cognitive impairments, falls and withdrawal effects. The production of melatonin, a physiological sleep and circadian rhythm regulator, declines with age. Prolonged-release melatonin (Circadin®), designed to mimic the endogenous pattern of melatonin production, is licensed for insomnia in patients aged ≥ 55 years. Areas covered: This review summarizes… Expand
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References

SHOWING 1-10 OF 139 REFERENCES
Efficacy of prolonged release melatonin in insomnia patients aged 55–80 years: quality of sleep and next-day alertness outcomes
  • 189
  • PDF
Melatonin replacement therapy of elderly insomniacs.
  • 336
  • PDF
Prolonged release melatonin in the treatment of primary insomnia: evaluation of the age cut-off for short- and long-term response
  • 72
  • PDF
Improvement of sleep quality in elderly people by controlled-release melatonin
  • 460
  • PDF
Prolonged-release melatonin for insomnia – an open-label long-term study of efficacy, safety, and withdrawal
  • 45
  • PDF
Nocturnal 6-sulfatoxymelatonin excretion in insomnia and its relation to the response to melatonin replacement therapy.
  • 140
  • PDF
Benzodiazepine discontinuation with prolonged-release melatonin: hints from a German longitudinal prescription database
  • 28
  • PDF
...
1
2
3
4
5
...