Prolonged reactive oxygen species generation and nuclear factor-kappaB activation after a high-fat, high-carbohydrate meal in the obese.

@article{Patel2007ProlongedRO,
  title={Prolonged reactive oxygen species generation and nuclear factor-kappaB activation after a high-fat, high-carbohydrate meal in the obese.},
  author={Chinmay Patel and Husam Ghanim and Shreyas Ravishankar and Chang Ling Sia and Prabhakar Viswanathan and Priya Ranjan Mohanty and Paresh Dandona},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2007},
  volume={92 11},
  pages={4476-9}
}
BACKGROUND Because obesity is associated with chronic oxidative and inflammatory stress, and high-fat, high-carbohydrate meals induce significant oxidative and inflammatory stress in normal subjects, we have now hypothesized that the intake of a high-fat, high-carbohydrate meal would result in a greater and more prolonged oxidative and inflammatory stress in the obese than in normal subjects. METHODS Ten normal-weight and eight obese subjects were given a high-fat, high-carbohydrate meal… CONTINUE READING