Prolonged prothrombin time as an early prognostic indicator of severe acute respiratory distress syndrome in patients with COVID-19 related pneumonia

  title={Prolonged prothrombin time as an early prognostic indicator of severe acute respiratory distress syndrome in patients with COVID-19 related pneumonia},
  author={Denis S. Baranovskii and Ilya D. Klabukov and Olga Aleksandrovna Krasilnikova and Dimitri A. Nikogosov and Natalia V. Polekhina and Delyara R. Baranovskaia and Leonid Aleksandrovich Laberko},
  journal={Current Medical Research and Opinion},
  pages={1 - 8}
Abstract Background Clinical observations demonstrated that COVID-19 related pneumonia is often accompanied by hematological and coagulation abnormalities including lymphopenia, thrombocytopenia, and prolonged prothrombin time. The evaluation of laboratory findings including coagulation and inflammation parameters may represent a promising approach for early determination of COVID-19 severity. Methods and Materials In the present study, we aimed to identify laboratory parameters present upon… 

Major coagulation disorders and parameters in COVID-19 patients

The most commonly reported problems of COVID-19 patients, such as venous thromboembolism, pulmonary emblism, disseminated intravascular coagulation, etc, are reviewed and the causes are investigated and the treatment options are briefly reviewed.

Involvement of the Liver in COVID-19: A Systematic Review

The important liver manifestations of COVID-19 are outlined, the possible underlying pathophysiological mechanisms and their diagnosis and management are discussed, and special emphasis is needed in those with nonalcoholic fatty liver disease, cirrhosis, hepatocellular carcinoma, hepatitis B and C infections, and alcoholic liver disease and in liver transplant recipients.

Comparison of Clinical Characteristics and Predictors of Mortality between Direct and Indirect ARDS.

The patients with direct ARDS were more likely to be older and male and have worse conditions and prognoses than those with indirect ARDS, suggesting the need for different management strategies of ARDS.

Prognostic Model of ICU Admission Risk in Patients with COVID-19 Infection Using Machine Learning

A stacking machine learning model was proposed and compared with eight different classification algorithms to detect risk of need for ICU admission for both COVID-19 and non-COVID patients combined and COVID patients alone, and the best performance was produced by the stacking approach.

Individual Characteristics as Prognostic Factors of the Evolution of Hospitalized COVID-19 Romanian Patients: A Comparative Observational Study between the First and Second Waves Based on Gaussian Graphical Models and Structural Equation Modeling

The main results highlight that the specific treatment methods applied had a positive influence on the evolution of COVID-19 patients, particularly in the second wave of coronavirus pandemic.

A complete framework for accurate recognition and prognosis of COVID-19 patients based on deep transfer learning and feature classification approach

The sudden appearance of COVID-19 has put the world in a serious situation. Due to the rapid spread of the virus and the increase in the number of infected patients and deaths, COVID-19 was declared

Inhibition of drug-metabolizing enzymes by Jingyin granules: implications of herb–drug interactions in antiviral therapy

Findings reveal that HEJG modulates the pharmacokinetics of CYP substrate-drug(s) by inactivating CYP3A, providing key information for both clinicians and patients to use herb–drug combinations for antiviral therapy in a scientific and reasonable way.

Original Abstracts from the 2022 European Meeting of ISMPP

The use of Twitter by pharmaceutical companies to publicise journal publications and engagement differences between plain language summary (PLS) formats of the journal Future Oncology showed that standalone PLSs provide a greater reach of information compared with other formats.



Clinical course and outcome of 107 patients infected with the novel coronavirus, SARS-CoV-2, discharged from two hospitals in Wuhan, China

A period of 7–13 days after illness onset is the critical stage in the COVID-19 course, which shows persistent lymphopenia, severe acute respiratory dyspnea syndrome, refractory shock, anuric acute kidney injury, coagulopathy, thrombocytopenia, and death.

COVID‐19 and the clinical hematology laboratory

The laboratory's role in the diagnosis of COVID‐19 infection is discussed, the current state of biomarker analysis in COVID'S infection is summarized, and the impact of the pandemic has had on organized national and international educational activities worldwide is described.

Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study

Severe acute respiratory syndrome coronavirus 2 infection can cause both pulmonary and systemic inflammation, leading to multi-organ dysfunction in patients at high risk, including patients with cardiovascular comorbidity.

Coagulation and inflammation biomarkers may help predict the severity of community‐acquired pneumonia

The aim of this study was to evaluate the association between the severity of CAP and serum levels of antithrombin III (AT‐III), protein C (P‐C), D‐dimers (D‐D) and CRP, at hospital admission.

Severe Outcomes Among Patients with Coronavirus Disease 2019 (COVID-19) — United States, February 12–March 16, 2020

COVID-19 cases in the United States that occurred during February 12-March 16, 2020 and severity of disease (hospitalization, admission to intensive care unit [ICU], and death) were analyzed by age group, suggesting that the risk for serious disease and death from CO VID-19 is higher in older age groups.

ISTH interim guidance on recognition and management of coagulopathy in COVID‐19

This work aims to contribute towards the humanizing of thrombosis and Haemostasis by promoting awareness of the importance of proper diagnosis and treatment of these conditions in patients.

Coronavirus Disease - COVID-19

The Coronavirus Disease - COVID-19 was depicted in the early days of the pandemic, but updated by more than 200 scientists and clinicians to include many facets of this new infectious pandemic.

Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia

In the recent outbreak of novel coronavirus infection in Wuhan, China, significantly abnormal coagulation parameters in severe novel coronavirus pneumonia (NCP) cases were a concern.