Prolonged preleukemic phase of chronic myelogenous leukemia.

  title={Prolonged preleukemic phase of chronic myelogenous leukemia.},
  author={S. David Hudnall and Jill Northup and Neli E Panova and Kauser Suleman and Gopalrao V N Velagaleti},
  journal={Experimental and molecular pathology},
  volume={83 3},
We report the detailed features of a unique case of a 33-year-old male in whom a large percentage of marrow (68%) and blood (31%) cells carried the Philadelphia chromosome by cytogenetics and FISH, as well as the p210 BCR-ABL transcript by RT-PCR, for 15 months prior to development of chronic myelogenous leukemia. The patient was closely followed throughout the preleukemic period with repeat blood and bone marrow analysis with no hematologic or pathologic evidence of leukemia, despite harboring… CONTINUE READING