Prolonged photoresponses in transgenic mouse rods lacking arrestin

  title={Prolonged photoresponses in transgenic mouse rods lacking arrestin},
  author={Jun Xu and Robert L. Dodd and Clint L. Makino and Melvin I. Simon and Denis A. Baylor and Jeannie Chen},
Arrestins are soluble cytoplasmic proteins that bind to G-protein-coupled receptors, thus switching off activation of the G protein and terminating the signalling pathway that triggers the cellular response,. Although visual arrestin has been shown to quench the catalytic activity of photoexcited, phosphorylated rhodopsin in a reconstituted system, its role in the intact rod cell remains unclear because phosphorylation alone reduces the catalytic activity of rhodopsin. Here we have recorded… CONTINUE READING
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Downregulation of cyclic GMP phosphodiesterase induced by expression of GTPase-deficient cone transducin in mouse rod photoreceptors

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