Prolonged photoresponses and defective adaptation in rods of Gbeta5-/- mice.

@article{Krispel2003ProlongedPA,
  title={Prolonged photoresponses and defective adaptation in rods of Gbeta5-/- mice.},
  author={Claudia M. Krispel and C Chen and Melvin I. Simon and Marie E Burns},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2003},
  volume={23 18},
  pages={6965-71}
}
Timely deactivation of G-protein signaling is essential for the proper function of many cells, particularly neurons. Termination of the light response of retinal rods requires GTP hydrolysis by the G-protein transducin, which is catalyzed by a protein complex that includes regulator of G-protein signaling RGS9-1 and the G-protein beta subunit Gbeta5-L… CONTINUE READING