Prolonged peritoneal gene expression using a helper-dependent adenovirus.

  title={Prolonged peritoneal gene expression using a helper-dependent adenovirus.},
  author={Limin Liu and Chang-xin Shi and Ayesha Ghayur and Claire Zhang and Je Yen Su and C. Michael Hoff and Peter J Margetts},
  journal={Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis},
  volume={29 5},
BACKGROUND Encapsulating peritoneal sclerosis (EPS) is a rare complication of peritoneal dialysis. The causes of EPS are not well defined and are likely multifactorial. A suitable animal model would facilitate research into the pathophysiology and treatment of EPS. METHODS We developed a helper-dependent adenovirus that expresses both green fluorescent protein (GFP) and active transforming growth factor-beta (TGF-beta1; HDAdTGF-beta1). Mice were administered HDAdTGF-beta1 via intraperitoneal… CONTINUE READING
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