Prolonged outpatient vitamin K antagonist use and risk of venous thromboembolism in patients undergoing total hip or knee replacement.

@article{Lalmohamed2013ProlongedOV,
  title={Prolonged outpatient vitamin K antagonist use and risk of venous thromboembolism in patients undergoing total hip or knee replacement.},
  author={Arief Lalmohamed and Peter Vestergaard and Paul A.F. Jansen and Erik Lerkevang Grove and Anthonius de Boer and Hubertus G. M. Leufkens and Tjeerd P van Staa and Frank de Vries},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2013},
  volume={11 4},
  pages={642-50}
}
BACKGROUND Long-term risk of venous thromboembolism (VTE) following total hip or knee replacement (THR/TKR) compared with controls has not been studied extensively, and the long-term influence of outpatient anticoagulant use on VTE risk remains unknown. The objectives were to evaluate long-term VTE risk following THR/TKR compared with matched controls, and to investigate effect modification by prolonged outpatient vitamin K antagonist use. METHODS A Danish retrospective nationwide cohort… CONTINUE READING