Prolonged oral transmucosal delivery of highly lipophilic drug cannabidiol.

@article{Itin2020ProlongedOT,
  title={Prolonged oral transmucosal delivery of highly lipophilic drug cannabidiol.},
  author={Constantin Itin and Dinorah Barasch and Abraham J. Domb and Amnon Hoffman},
  journal={International journal of pharmaceutics},
  year={2020},
  pages={
          119276
        }
}
Delivery of drugs through oral mucosa enables bypass of the gastrointestinal tract and "first pass" metabolism in the liver and the gut. Thus, a higher and less variable bioavailability can be obtained. Mechanisms of this administration route for cannabidiol were investigated in the current research in pigs. Results show that cannabidiol has substantially low permeability rate over 8 hours through oral mucosa and accumulates significantly within it. Furthermore, following the removal of the… 
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