Prolonged oral transmucosal delivery of highly lipophilic drug cannabidiol.

  title={Prolonged oral transmucosal delivery of highly lipophilic drug cannabidiol.},
  author={Constantin Itin and Dinorah Barasch and Abraham J. Domb and Amnon Hoffman},
  journal={International journal of pharmaceutics},

Strategies for enhancing the oral bioavailability of cannabinoids

The different influence over the absorption pathway illuminates the importance of understanding the absorption mechanism and its barriers to properly select appropriate strategies to achieve enhanced oral bioavailability.

Mucoadhesion and Mucopenetration of Cannabidiol (CBD)-Loaded Mesoporous Carrier Systems for Buccal Drug Delivery

The development of silica-based buccal drug delivery systems is a promising approach for the effective delivery of CBD and chitosan represents a promising polymer to combine both effects.

Mucosal Delivery of Cannabidiol: Influence of Vehicles and Enhancers

In this study, the mucosal permeation and deposition of cannabidiol with neat and binary vehicles were investigated and useful basic information is provided for the development of CBD formulations intended for transmucosal delivery.

Development of Stable Nano-Sized Transfersomes as a Rectal Colloid for Enhanced Delivery of Cannabidiol

Transfersomes showed significant promise that the transfersomes promoted rectal tissue permeation with superior stability and afforded tunable release kinetics of CBD as a botanical therapeutic with inherent poor bioavailability.

Emulsion, hydrogel and emulgel systems and novel applications in cannabinoid delivery: a review

An overview ofEmulsions, hydrogels and emulgels have attracted a high interest as tools for the delivery of poorly soluble hydrophobic nutraceuticals by enhancing their stability and bioavailability and their interactions with the human gastrointestinal system.

Pharmacokinetics of Cannabidiol Following Intranasal, Intrarectal, and Oral Administration in Healthy Dogs

IN administration of CBD resulted in faster absorption when compared to PO administration, however, PO remains the most favorable route for CBD delivery due to its more feasible administration.

In Vitro Release, Mucosal Permeation and Deposition of Cannabidiol from Liquisolid Systems: The Influence of Liquid Vehicles

This work investigated the influence of liquid vehicles on the release, mucosal permeation and deposition of cannabidiol (CBD) from liquisolid systems. Various vehicles, including EtOH, nonvolatile



Effect of Drug Lipophilicity and Ionization on Permeability Across the Buccal Mucosa: A Technical Note

It was hypothesized that logD describes buccal permeation better than logP, the most widely used predictor for drug permeation, and the correlation of logP and logD with buCCal permeability was compared.

A meta-opinion: cannabinoids delivered to oral mucosa by a spray for systemic absorption are rather ingested into gastro-intestinal tract: the influences of fed / fasting states

It is hypothesized that these cannabinoids are ingested and absorbed in the gastrointestinal tract and would enable predicting the impact of different physiological parameters such as saliva flow and fed/fasting states on the pharmacokinetics of the delivered medication.

Drug recovery following buccal absorption of propranolol.

Large amounts of propranolol were recoverable from the buccal mucosa; recovery was biexponential and the amount recovered depended on the time allowed for absorption and on the pH of buffers used for recovery.

Buccal permeation of buspirone: mechanistic studies on transport pathways.

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The buccal mucosa as an alternative route for the systemic delivery of risperidone.

Investigation of the buccal mucosa for the systemic delivery of risperidone (RISP) and the impact of Azone® (AZ) on the transport of RISP via this route found it to result in therapeutically relevant plasma concentrations for the treatment of schizophrenia.

Transdermal and Buccal Delivery of Methylxanthines Through Human Tissue In Vitro

In vitro permeation of central nervous stimulants—caffeine, theophylline, and theobromine across human skin with the aid of six chemical enhancers found that oleic acid was the most potent enhancer for all three methylxanthines.

Peptide Washout and Permeability from Glyceryl Monooleate Buccal Delivery Systems

The donor compartment flow-through diffusion cell was found to be a useful tool to evaluate the impact of salivary washout on mucoadhesive oral mucosal delivery systems.

Recent advances in buccal drug delivery and absorption--in vitro and in vivo studies.