Prolonged nuclear retention of activated extracellular signal-regulated kinase 1/2 is required for hepatocyte growth factor-induced cell motility.

@article{Tanimura2002ProlongedNR,
  title={Prolonged nuclear retention of activated extracellular signal-regulated kinase 1/2 is required for hepatocyte growth factor-induced cell motility.},
  author={Susumu Tanimura and Kayo Nomura and Kei-ichi Ozaki and Masafumi Tsujimoto and Takahito Kondo and Michiaki Kohno},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 31},
  pages={28256-64}
}
We examined the signaling pathway by which hepatocyte growth factor (HGF) induces cell motility, with special focus on the role of extracellular signal-regulated kinase (ERK) in the nucleus. We used Madin-Darby canine kidney cells overexpressing ERK2 because of their prominent motility response to HGF. HGF stimulation of the cells induces not only a rapid, marked, and sustained activation and rapid nuclear accumulation of ERK1/2, but also a prolonged nuclear retention of the activated ERK1/2… CONTINUE READING
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