Prolonged morphine treatment alters δ opioid receptor post-internalization trafficking

@inproceedings{Ong2015ProlongedMT,
  title={Prolonged morphine treatment alters δ opioid receptor post-internalization trafficking},
  author={Edmund W. Ong and L. Q. Xue and Mary C Olmstead and Catherine M Cahill},
  booktitle={British journal of pharmacology},
  year={2015}
}
BACKGROUND AND PURPOSE The δ opioid receptor (DOP receptor) undergoes internalization both constitutively and in response to agonists. Previous work has shown that DOP receptors traffic from intracellular compartments to neuronal cell membranes following prolonged morphine treatment. Here, we examined the effects of prolonged morphine treatment on the post-internalization trafficking of DOP receptors. EXPERIMENTAL APPROACH Using primary cultures of dorsal root ganglia neurons, we measured the… CONTINUE READING
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