Prolonged monitoring of ethinyl estradiol and levonorgestrel levels confirms an altered pharmacokinetic profile in obese oral contraceptives users.

@article{Edelman2013ProlongedMO,
  title={Prolonged monitoring of ethinyl estradiol and levonorgestrel levels confirms an altered pharmacokinetic profile in obese oral contraceptives users.},
  author={Alison B. Edelman and Ganesh Cherala and Myrna Y. Munar and Barent Dubois and Martha McInnis and Frank Z. Stanczyk and Jeffrey T Jensen},
  journal={Contraception},
  year={2013},
  volume={87 2},
  pages={
          220-6
        }
}
BACKGROUND Pharmacokinetic (PK) parameters based on short sampling times (48 h or less) may contain inaccuracies due to their dependency on extrapolated values. This study was designed to measure PK parameters with greater accuracy in obese users of a low-dose oral contraceptive (OC) and to correlate drug levels with assessments of end-organ activity. STUDY DESIGN Obese [body mass index (BMI) ≥30 kg/m2], ovulatory, otherwise healthy women (n=32) received an OC containing 20 mcg ethinyl… CONTINUE READING
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