Prolonged methylphenidate treatment alters the behavioral diurnal activity pattern of adult male Sprague-Dawley rats.

@article{Algahim2009ProlongedMT,
  title={Prolonged methylphenidate treatment alters the behavioral diurnal activity pattern of adult male Sprague-Dawley rats.},
  author={Mohamed F. Algahim and Pamela Yang and Victor T. Wilcox and Keith Dean Burau and Alan C. Swann and Nachum Dafny},
  journal={Pharmacology, biochemistry, and behavior},
  year={2009},
  volume={92 1},
  pages={93-9}
}
Methylphenidate (MPD) is becoming a drug of abuse among adult professionals and students, alike. Yet, few studies have investigated its long-term effects on the adult population. We hypothesized that prolonged administration of MPD leads to changes in the diurnal horizontal activity (HA) pattern, an effect persisting beyond acute drug effects. Four groups of adult male Sprague-Dawley rats (N=32) were divided into a saline/control, 0.6, 2.5, or 10.0 mg/kg MPD group. Each group was treated with… CONTINUE READING