Prolonged low-dose administration of the cyclooxygenase-2 inhibitor celecoxib enhances the antitumor activity of irinotecan against neuroblastoma xenografts.

Abstract

Cyclooxygenase (COX)-2 is overexpressed in many human tumors including neuroblastoma (NB) and promotes tumor progression. We evaluated the antitumor effect of irinotecan (CPT-11) treatment combined with prolonged very low-dose administration of celecoxib, a selective COX-2 inhibitor, against three human NB xenografts, TNB9, TS-N-2nu, and TS-N-5nu. In… (More)
DOI: 10.1111/j.1349-7006.2009.01280.x

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@article{Kaneko2009ProlongedLA, title={Prolonged low-dose administration of the cyclooxygenase-2 inhibitor celecoxib enhances the antitumor activity of irinotecan against neuroblastoma xenografts.}, author={Michio Kaneko and Setsuko Kaneko and Kenshi Suzuki}, journal={Cancer science}, year={2009}, volume={100 11}, pages={2193-201} }