Prolonged intermittent but not continuous administration of oestradiol-17 beta increases bone volume in the rat.

Abstract

We have previously found that administration of oestradiol-17 beta (OE2) to intact adult female rats of 19 days stimulates cancellous bone formation. However, this effect is not observed following longer periods of OE2 treatment, suggesting that the responsiveness of the skeleton to oestrogen's anabolic action is reduced after prolonged administration. A… (More)

Topics

Cite this paper

@article{Tobias1993ProlongedIB, title={Prolonged intermittent but not continuous administration of oestradiol-17 beta increases bone volume in the rat.}, author={Jon H. Tobias and A. Gallagher and Tim J. Chambers}, journal={The Journal of endocrinology}, year={1993}, volume={139 2}, pages={267-73} }