Prolonged inhibition of growth hormone secretion by peripheral injection of bombesin is mediated by somatostatin in the rat.

Abstract

Peripherally injected bombesin inhibits GH secretion in conscious, freely moving rats and in sodium pentobarbital-anesthetized rats. This inhibition of GH secretion is unusually prolonged, lasting up to 90 min after a single ip injection. The duration of inhibition of GH secretion by bombesin is greater than that observed for somatostatin (SRIF) in the same… (More)

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@article{Murphy1985ProlongedIO, title={Prolonged inhibition of growth hormone secretion by peripheral injection of bombesin is mediated by somatostatin in the rat.}, author={William J. Murphy and Valentine A. Lance and M L Heiman and Simon J. Hocart and David H. Coy}, journal={Endocrinology}, year={1985}, volume={117 3}, pages={1179-83} }