Prolonged in vivo tumour retention of a human diabody targeting the extracellular domain of human HER2/neu.

@article{Adams1998ProlongedIV,
  title={Prolonged in vivo tumour retention of a human diabody targeting the extracellular domain of human HER2/neu.},
  author={Gregory P. Adams and Robert Schier and Adrian M. McCall and R. S. Crawford and Ellen J. Wolf and Louis M. Weiner and James D Marks},
  journal={British Journal of Cancer},
  year={1998},
  volume={77},
  pages={1405 - 1412}
}
Single-chain Fv (scFv) molecules exhibit highly specific tumour-targeting properties in tumour-bearing mice. However, because of their smaller size and monovalent binding, the quantities of radiolabelled scFv retained in tumours limit their therapeutic applications. Diabodies are dimeric antibody-based molecules composed of two non-covalently associated scFv that bind to antigen in a divalent manner. In vitro, diabodies produced from the anti-HER2/neu (c-erbB-2) scFv C6.5 displayed… CONTINUE READING

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