Prolonged hypoxic culture and trypsinization increase the pro-angiogenic potential of human adipose tissue-derived stem cells.

@article{Rasmussen2011ProlongedHC,
  title={Prolonged hypoxic culture and trypsinization increase the pro-angiogenic potential of human adipose tissue-derived stem cells.},
  author={Jeppe Gr{\o}ndahl Rasmussen and Ole Fr{\o}bert and Linda Pilgaard and Jens Kastrup and Ulf Simonsen and Vladimir Zachar and Trine Fink},
  journal={Cytotherapy},
  year={2011},
  volume={13 3},
  pages={
          318-28
        }
}
BACKGROUND AIMS Transplantation of mesenchymal stromal cells (MSC), including adipose tissue-derived stem cells (ASC), is a promising option in the treatment of vascular disease. Short-term hypoxic culture of MSC augments secretion of anti-apoptotic and angiogenic cytokines. We hypothesized that prolonged hypoxic (1% and 5% oxygen) culture and trypsinization would augment ASC expression of anti-apoptotic and angiogenic cytokines and increase the angiogenic potential of ASC-conditioned media… CONTINUE READING

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