Prolonged hepatic cholestasis after flucloxacillin therapy.

  title={Prolonged hepatic cholestasis after flucloxacillin therapy.},
  author={I B Turner and Robert P. Eckstein and James Whitcomb Riley and Mark Lunzer},
  journal={The Medical journal of Australia},
  volume={151 11-12},
A severe prolonged illness that was characterized by deep jaundice and debilitating pruritus occurred in five patients after the use of flucloxacillin. The symptoms and signs of liver disease took at least two months to resolve; after four- to nine-months' follow-up, liver enzyme activities have remained abnormal in all patients. Examination of liver biopsy specimens showed severe cholestasis in all cases, with evidence of significant bile-duct injury in three cases. In one patient, in whom… CONTINUE READING


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