Prolonged half-life and preserved enzymatic properties of factor IX selectively PEGylated on native N-glycans in the activation peptide.

@article{stergaard2011ProlongedHA,
  title={Prolonged half-life and preserved enzymatic properties of factor IX selectively PEGylated on native N-glycans in the activation peptide.},
  author={Henrik \Ostergaard and Jais R Bjelke and Lene Gram Hansen and Lars Christian Petersen and Anette Amstrup Pedersen and Torben Elm and Flemming M\oller and Mette Brunsgaard Hermit and Pernille K Holm and Thomas Nylandsted Krogh and J\orn Meidahl Petersen and Mirella Ezban and B B S\orensen and Mette Dahl Andersen and Henrik Agers\o and Haleh Ahmadian and Kristoffer W. Balling and Marie Louise S Christiansen and Karin E Knobe and Timothy C Nichols and S\oren Erik Bj\orn and Mikael Tranholm},
  journal={Blood},
  year={2011},
  volume={118 8},
  pages={2333-41}
}
Current management of hemophilia B entails multiple weekly infusions of factor IX (FIX) to prevent bleeding episodes. In an attempt to make a longer acting recombinant FIX (rFIX), we have explored a new releasable protraction concept using the native N-glycans in the activation peptide as sites for attachment of polyethylene glycol (PEG). Release of the activation peptide by physiologic activators converted glycoPEGylated rFIX (N9-GP) to native rFIXa and proceeded with normal kinetics for FXIa… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 49 extracted citations

Nonacog Beta Pegol: A Review in Haemophilia B

Drugs • 2017
View 9 Excerpts
Highly Influenced

Pharmacokinetics, tissue distribution, excretion, and metabolite profiling of PEGylated rFIX (nonacog beta pegol, N9-GP) in rats.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences • 2016
View 5 Excerpts
Highly Influenced

GlycoPEGylated recombinant factor IX for hemophilia B in context

Drug design, development and therapy • 2018
View 4 Excerpts
Highly Influenced

Recent advances in hemophilia B therapy

Drug Delivery and Translational Research • 2017

References

Publications referenced by this paper.
Showing 1-10 of 55 references

A ferric chloride induced arterial injury model used as haemostatic effect model.

Haemophilia : the official journal of the World Federation of Hemophilia • 2010

Functional characteristics of N8, a new recombinant FVIII.

Haemophilia : the official journal of the World Federation of Hemophilia • 2010

Safety and efficacy of investigator - prescribed BeneFIX prophylaxis in children less than 6 years of age with severe haemophilia B

VS Blanchette, M Manco-Johnson, E Santagostino, R Ljung
Haemophilia • 2010

timizing thrombelastography ( TEG ) assay conditions to monitor rFVIIa ( NovoSeven ) therapy in haemophilia A patients

D Viuff, S Andersen, BB Sorensen, S Lethagen
Thromb Res • 2010

Similar Papers

Loading similar papers…