Prolonged gray matter disease without demyelination caused by Theiler's murine encephalomyelitis virus with a mutation in VP2 puff B.

@article{Tsunoda2001ProlongedGM,
  title={Prolonged gray matter disease without demyelination caused by Theiler's murine encephalomyelitis virus with a mutation in VP2 puff B.},
  author={Ikuo Tsunoda and Yoshiaki Wada and Jane E. Libbey and Tom Cannon and Frank G. Whitby and Robert Shin Fujinami},
  journal={Journal of virology},
  year={2001},
  volume={75 16},
  pages={7494-505}
}
Theiler's murine encephalomyelitis virus (TMEV) is divided into two subgroups based on neurovirulence. During the acute phase, DA virus infects cells in the gray matter of the central nervous system (CNS). Throughout the chronic phase, DA virus infects glial cells in the white matter, causing demyelinating disease. Although GDVII virus also infects neurons in the gray matter, infected mice developed a severe polioencephalomyelitis, and no virus is detected in the white matter or other areas in… CONTINUE READING
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