Prolonged glucocorticoid treatment is associated with improved ARDS outcomes: analysis of individual patients’ data from four randomized trials and trial-level meta-analysis of the updated literature

@article{Meduri2015ProlongedGT,
  title={Prolonged glucocorticoid treatment is associated with improved ARDS outcomes: analysis of individual patients’ data from four randomized trials and trial-level meta-analysis of the updated literature},
  author={Gianfranco Umberto Meduri and Lisa Bridges and M Shih and Paul Ellis Marik and Reed Alexander C Siemieniuk and Mehmet Kocak},
  journal={Intensive Care Medicine},
  year={2015},
  volume={42},
  pages={829-840}
}
To investigate the effect of prolonged glucocorticoid treatment for patients with acute respiratory distress syndrome (ARDS). We conducted two sets of intention-to-treat analyses: (1) a primary analysis of individual patients’ data (IPD) of four randomized controlled trials (RCTs) which investigated methylprednisolone treatment (n = 322) and (2) a trial-level meta-analysis incorporating four additional RCTs which investigated hydrocortisone treatment in early ARDS (n = 297). We standardized… CONTINUE READING
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