Prolonged exposure to particulate chromate inhibits RAD51 nuclear import mediator proteins.


Particulate hexavalent chromium (Cr(VI)) is a human lung carcinogen and a human health concern. The induction of structural chromosome instability is considered to be a driving mechanism of Cr(VI)-induced carcinogenesis. Homologous recombination repair protects against Cr(VI)-induced chromosome damage, due to its highly accurate repair of Cr(VI)-induced DNA… (More)
DOI: 10.1016/j.taap.2017.05.030