Prolonged exposure to inhalational anesthetic nitrous oxide kills neurons in adult rat brain

@article{JevtovicTodorovic2003ProlongedET,
  title={Prolonged exposure to inhalational anesthetic nitrous oxide kills neurons in adult rat brain},
  author={Vesna Jevtovic-Todorovic and Jacquelyn K Beals and Nicholas D. Benshoff and John W. Olney},
  journal={Neuroscience},
  year={2003},
  volume={122},
  pages={609-616}
}
Short-term exposure of adult rats to nitrous oxide (N2O), an inhalational anesthetic and NMDA (N-methyl-D-aspartate) antagonist, causes a reversible neurotoxic vacuole reaction in neurons of the posterior cingulate/retrosplenial cortex (PC/RSC) which resembles that caused by low doses of other NMDA antagonists. Since high doses or prolonged exposure to other NMDA antagonists can cause neurons to die, we assessed whether prolonged N2O exposure might also cause neuronal cell death. Adult female… Expand
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