Prolonged exposure to ammonia increases extracellular glutamate in cultured rat astrocytes.

@article{Ohara2009ProlongedET,
  title={Prolonged exposure to ammonia increases extracellular glutamate in cultured rat astrocytes.},
  author={Kentaro Ohara and Mineyoshi Aoyama and Masataka Fujita and Kazuya Sobue and Kiyofumi Asai},
  journal={Neuroscience letters},
  year={2009},
  volume={462 2},
  pages={109-12}
}
Abnormal alteration of brain function is a characteristic complication of hepatic encephalopathy in both acute and chronic liver failure. Previous studies suggest that the pathogenesis of hepatic encephalopathy involves chronic glial edema with subsequent alteration of glioneuronal communication, N-methyl-d-aspartate (NMDA) receptor activation, and oxidative/nitrosative stress. In the present study, we investigated extracellular glutamate levels in cultured astrocytes under prolonged exposure… CONTINUE READING

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