Prolonged exposure to IL-1β and IFNγ induces necrosis of L929 tumor cells via a p38MAPK/NF-κB/NO-dependent mechanism

Abstract

Interleukin-1β (IL-1β) is a cytokine that shares with tumor necrosis factor (TNF) the ability to initiate largely similar signaling pathways, leading to proinflammatory gene expression. In contrast to TNF, however, IL-1β is not believed to induce tumor cell death. Here we demonstrate that prolonged treatment with IL-1β, in combination with interferon-γ (IFN… (More)
DOI: 10.1038/onc.2008.4

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@article{Vercammen2008ProlongedET, title={Prolonged exposure to IL-1β and IFNγ induces necrosis of L929 tumor cells via a p38MAPK/NF-κB/NO-dependent mechanism}, author={Els Vercammen and Jens Staal and Anne van den Broeke and Mira Haegman and Lars Vereecke and Peter Schotte and Rudi Beyaert}, journal={Oncogene}, year={2008}, volume={27}, pages={3780-3788} }