Prolonged exposure of rats to intravenous methamphetamine: behavioral and neurochemical characterization

@article{Segal2005ProlongedEO,
  title={Prolonged exposure of rats to intravenous methamphetamine: behavioral and neurochemical characterization},
  author={David S. Segal and Ronald Kuczenski and Meghan L. O’Neil and William P. Melega and Arthur K. Cho},
  journal={Psychopharmacology},
  year={2005},
  volume={180},
  pages={501-512}
}
The translational value of preclinical models of methamphetamine abuse depends in large part on the degree to which the drug regimens used in animals produce methamphetamine exposure patterns similar to those experienced by human methamphetamine abusers. To approximate one common form of methamphetamine abuse, we studied the effects of a schedule of intravenous methamphetamine administration in rats which included 2 weeks of progressively more frequent drug injections (0.125 mg/kg/injection… CONTINUE READING
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