Prolonged exercise causes an increase in endothelin-1 production in the heart in rats.

@article{Maeda1998ProlongedEC,
  title={Prolonged exercise causes an increase in endothelin-1 production in the heart in rats.},
  author={Seiji Maeda and Takashi Miyauchi and Satoshi Sakai and Tsutomu Kobayashi and Motoyuki Iemitsu and Katsutoshi Goto and Yasuro Sugishita and Mitsuo Matsuda},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={1998},
  volume={275 6},
  pages={H2105-H2112}
}
Cardiac myocytes produce endothelin-1 (ET-1). ET-1 has potent positive inotropic and chronotropic effects. We investigated whether production of ET-1 in the heart is altered by prolonged exercise in rats. Rats ran on a treadmill for 45 min. Immediately after this exercise the heart and lungs were quickly removed. Control rats remained at rest during this 45-min period. Expression of preproET-1 mRNA in the heart was markedly higher in the exercised than in the control rats. The peptide level of… CONTINUE READING

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