Prolonged digitoxin half-life in very elderly patients.

  title={Prolonged digitoxin half-life in very elderly patients.},
  author={T Bohmer and Arne Gustav R\oseth},
  journal={Age and ageing},
  volume={27 2},
The digitoxin half-life in elderly patients in the eight and ninth decade was more prolonged (mean +/- SD: 25 +/- 9 days) than in younger people (6.7 +/- 1.7). These elderly patients accumulated digitoxin even on a dose of 0.05 mg/ day. The symptoms of digitoxin intoxication disappeared on discontinuation of medication. When digitoxin is used in the treatment for heart failure in the very elderly patients, one should be aware of the possibility of digitoxin intoxication, even on a low dose.